Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester
N-Benzyloxycarbonyl-D-phenylanlaninol
CAS: 58917-85-4
Molecular Formula: C17H19NO3
Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester - Names and Identifiers
| Name | N-Benzyloxycarbonyl-D-phenylanlaninol |
| Synonyms | Cbz-D-Phenylalanino Cbz-D-Phenylalaninol N-CBZ-D-PHENYLALANINOL N-CARBOBENZOXY-D-PHENYLALANINOL N-(CARBOBENZYLOXY)-D-PHENYLALANINOL N-Benzyloxycarbonyl-D-phenylanlaninol (R)-(+)-2-(Cbz-aMino)-3-phenyl-1-propanol Benzyl [(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamate Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester (R)-N-Carbobenzoxy-2-amino-3-phenyl-1-propanol(R)-N-Cbz-2-amino-3-phenyl-1-propanolN-Cbz-D-phenylalaninol |
| CAS | 58917-85-4 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C17H19NO3/c19-12-16(11-14-7-3-1-4-8-14)18-17(20)21-13-15-9-5-2-6-10-15/h1-10,16,19H,11-13H2,(H,18,20)/t16-/m1/s1 |
Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester - Physico-chemical Properties
| Molecular Formula | C17H19NO3 |
| Molar Mass | 285.34 |
| Density | 1.0864 (rough estimate) |
| Melting Point | 92-95°C |
| Boling Point | 427.77°C (rough estimate) |
| Specific Rotation(α) | 30 º (c=1 in chloroform) |
| Flash Point | 249.6°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 2.23E-10mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 2221968 |
| pKa | 11.86±0.46(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 42 ° (C=2, MeOH) |
| MDL | MFCD00191193 |
Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29051990 |
Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, phenylmethyl ester - Introduction
N-Benzyloxycarbonyl-D-phenylanlaninol is an organic compound with the chemical formula C19H19NO3.
Its properties are as follows:
-Appearance: White crystalline powder
-melting point: about 108-111 ℃
-Solubility: Soluble in ethanol, chloroform and dichloromethane, insoluble in water
The main uses of the N-Benzyloxycarbonyl-D-phenylanlaninol are as follows:
-Intermediates in organic synthesis: can be used to synthesize other organic compounds.
-Drug research and development: It can be used to synthesize precursors or intermediates of some drugs, such as peptide drugs.
N-Benzyloxycarbonyl-D-phenylanlaninol preparation method can generally be carried out through the following steps:
1. Dissolve D-phenylalaninol in dichloromethane.
2. adding acetal agent N-benzyloxyformaldehyde and acid catalyst.
3. After completion of the reaction, crystallization separation, washing and drying were performed to obtain the target product.
Regarding safety information, the toxicity of N-Benzyloxycarbonyl-D-phenylanlaninol is low, but the following matters still need to be noted:
-Avoid contact with skin and eyes, such as accidental contact, should immediately rinse with plenty of water.
-Avoid inhaling dust or gas during operation to ensure that the operating place is well ventilated.
-Must operate under safe controlled conditions, using protective gloves, goggles and other personal protective equipment.
Its properties are as follows:
-Appearance: White crystalline powder
-melting point: about 108-111 ℃
-Solubility: Soluble in ethanol, chloroform and dichloromethane, insoluble in water
The main uses of the N-Benzyloxycarbonyl-D-phenylanlaninol are as follows:
-Intermediates in organic synthesis: can be used to synthesize other organic compounds.
-Drug research and development: It can be used to synthesize precursors or intermediates of some drugs, such as peptide drugs.
N-Benzyloxycarbonyl-D-phenylanlaninol preparation method can generally be carried out through the following steps:
1. Dissolve D-phenylalaninol in dichloromethane.
2. adding acetal agent N-benzyloxyformaldehyde and acid catalyst.
3. After completion of the reaction, crystallization separation, washing and drying were performed to obtain the target product.
Regarding safety information, the toxicity of N-Benzyloxycarbonyl-D-phenylanlaninol is low, but the following matters still need to be noted:
-Avoid contact with skin and eyes, such as accidental contact, should immediately rinse with plenty of water.
-Avoid inhaling dust or gas during operation to ensure that the operating place is well ventilated.
-Must operate under safe controlled conditions, using protective gloves, goggles and other personal protective equipment.
Last Update：2024-04-09 20:02:46
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CAS: 58917-85-4
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Mobile: 18021002903
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